Key hub genes such as SLC22A3, FOXP2, Cdc42EP3, COL27A1, DUSP1, and HSPB8 are central players in ACC due to their involvement in signaling pathways correlated to ACC, such as SOX2, AR, SMAD, and MAPK [27]. This evidence concerns the gene COL27A1 and adrenal cortex carcinoma.