Zoico et al. described that the dedifferentiation of 3T3-L1 adipocytes was induced when they were co-cultured with a pancreatic carcinoma cell line, MIA PaCa-2, or cultured with conditioned media, and showed that the inhibition of a WNT5a signal with an anti-WNT5 antibody inhibited dedifferentiation [33]. Here, WNT5A is linked to exocrine pancreatic carcinoma.