Both sexes showed a considerable increase in PCs, a decrease in C16:0 with an increase in C28:1 LysoPCs, an increase in sphingomyelins, as well as an increase in symmetric dimethylarginine (SDMA), acetyl-ornithine, and hydroxyproline.  Twenty-nine metabolites, involved in phospholipidic and cardiac remodeling, arginine/nitric oxide pathway, and antihypertensive and insulin resistance mechanisms, discriminated the metabolic sexual dimorphism of hypertension. The gene discussed is INS; the disease is Hypertension.