Although the pattern of seizures in FXS mostly resemble benign childhood epilepsy with centrotemporal spikes [237,354], an involvement of the hippocampus in childhood epilepsy can be possible [355] considering the anatomical and functional alterations of the FXS hippocampus and the fact that FMRP is highly expressed in the hippocampus [247,267,354,356,357]. This evidence concerns the gene FMR1 and fragile X syndrome.