Through the enrichment of 124 hub genes, the molecular signaling pathways of hypertensive disease, congestive heart failure, heart failure, neoplasm and carcinogenesis, PI3K-Akt, endochondral ossification, extracellular organization, oncostatin M signaling, cardiac troponin T level, plasma plasminogen activation levels, and biological processes that are associated with these hub genes were brought to light (Figure 1c). The gene discussed is AKT1; the disease is heart failure.