The enrichment of 119 hub genes elucidated the molecular signaling pathways related to atherosclerosis, myocardial infarction, the PI3K-Akt signaling pathway, the HIF1 signaling pathway, the Toll-like receptor signaling pathway, IL-18 signaling and hypertrophic cardiomyopathy and biological processes associated with these hub genes (Figure 2c). This evidence concerns the gene IL18 and hypertrophic cardiomyopathy.