MMP-7 directly cut off the E-cadherin ectodomain releasing an 80 kDa fragment involved in the inhibition of epithelial cell aggregation and cell invasion induction in a paracrine manner [40]; MMP9, also known as gelatinase B, plays an important role in ECM remodeling and is associated with tumor invasion, metastasis, and modulation of tumor microenvironment. This evidence concerns the gene MMP9 and neoplasm.