CDH1 and neoplasm: MMP-7 directly cut off the E-cadherin ectodomain releasing an 80 kDa fragment involved in the inhibition of epithelial cell aggregation and cell invasion induction in a paracrine manner [40]; MMP9, also known as gelatinase B, plays an important role in ECM remodeling and is associated with tumor invasion, metastasis, and modulation of tumor microenvironment.