Similarly, STAT3 activation by inflammatory cytokines such as IL-6 and TNF-α establishes an oncogenic feedback loop by upregulating anti-apoptotic proteins (e.g., Bcl-2, Mcl-1), promoting immune evasion, and facilitating epithelial–mesenchymal transition (EMT), which further drives tumor progression and metastasis [132]. This evidence concerns the gene IL6 and neoplasm.