Our existing results supported that the apoptosis, pyroptosis, and autophagy activity of breast cancer tissues could significantly affect the prognosis of BC patients; that is, high-apoptosis, high-pyroptosis, and low-autophagy states could improve the BC prognosis underlying the mechanisms of the obvious immune-activated features and similar microenvironment states, via the more anti-tumor immune responses, specifically, mainly achieved through promoting macrophage polarization towards anti-tumorigenic M1 macrophages and high CD8+ T cells, Tfh and Tregs cells. The gene discussed is CD8A; the disease is neoplasm.