By integrating multi-dimensional analyses of 13 PCD patterns, our study provides novel insights for understanding the PCD-TME-interaction-axis-driven breast cancer progression and prognosis and highlights that high apoptosis/pyroptosis and low autophagy states correlate with favorable prognosis, driven by enhanced anti-tumor immunity—specifically M1 macrophage polarization and CD8+ T cell activation. Here, CD8A is linked to breast cancer.