PIK3CA and cancer: The brown module was also enriched in NF-κB signaling pathways, many processes of immune response (natural-killer-cell-mediated cytotoxicity, Th1 and Th2 cell differentiation, PD-L1 expression and PD-1 checkpoint pathways in cancer, cytokine signaling, IL18 signaling pathways, and T cell modulation in pancreatic cancer, HIF-1 signaling, PI3K-Akt signaling, MAPK pathways, and JAK-STAT pathways (Figure 3F)).