POLE and endometrial cancer: Inspired by these findings, A Talhouk et al. developed a simplified classifier, termed Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE), which identifies four molecular subtypes that are analogous but not identical to the four genomic subtypes described in TCGA: POLE exonuclease domain mutated (POLE EDM), mismatch repair deficient (MMRd), p53 wild-type/CNL (p53wt), and p53-mutated/CNH (p53abn) [6].