To disentangle episodic memory network changes related to aging independent of AD pathology and neurodegenerative pathogenesis, we quantified longitudinal changes in rsFC in a group of cognitively unimpaired older adults (a) with a negative amyloid- and tau biomarker status and (b) with available longitudinal AD biomarker data (independent of biomarker status). This evidence concerns the gene MAPT and Alzheimer disease.