APP and cerebral amyloid angiopathy: We analysed two mutation sets: i) 28 PSEN2 mutations scattered throughout the PSEN primary sequence, classified as pathogenic,'likely pathogenic','variants of unclear significance', and benign (serving as controls) (Table 1), and ii) 18 APP (TMD) mutations, classified as ADAD pathogenic or variants of unclear significance, including one APP (TMD) mutation associated with pure cerebral amyloid angiopathy CAA (L705V) [32].