BP, blood pressure; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; eGFR (CKD-EPI), estimated glomerular filtration rate according to the Chronic Kidney Disease Epidemiology Collaboration equation; LA, left atrium; LV, left ventricle; NT-proBNP, N-terminal pro B-type natriuretic peptide; NYHA, New York Heart Association; TR, tricuspid regurgitation. The gene discussed is NPPB; the disease is chronic obstructive pulmonary disease.