In order to deeply characterize the responses of GAMs to integrin and/or immune-check-point blockade, transcriptome profiling of CD11b+ cells isolated from the brains of tumor-bearing mice at 28 DPI was performed using RNA-seq. The most profound changes versus the vehicle group were detected upon the combination treatment with 7aaRGD and anti-PD-1 (RGD + aPD-1) (Fig. 5A). This evidence concerns the gene ITGAM and neoplasm.