SPP1 and central nervous system cancer: As a strategy to prevent the reprogramming of myeloid cells into GAMs, we designed a synthetic 7-amino-acid peptide with the RGD motif (‘7aaRGD’), which competitively blocked the interactions of SPP1 and MFG-E8 with the integrins, abolished the activation of the focal adhesion kinase-dependent signaling pathway, decreased microglial phagocytosis and migration, and reduced the expression of proinvasive phenotype genes in glioma secretome-stimulated microglia [21].