We previously identified two glioma-derived αvβ3/αvβ5-integrin receptors ligands, osteopontin/secreted phosphoprotein 1 (SPP1) and lactadherin/milk fat globule-epidermal growth factor 8 (MFG-E8), as activators of myeloid cell reprogramming in gliomas [21]. This evidence concerns the gene SPP1 and central nervous system cancer.