Given that immunoblotting of somatic mouse tissues (thymus and liver) also solely identified CENP-A, unlike human lymphoma cells where CENP-B and CENP-C were recognised (del Mazo et al. 1987), it is possible that CREST serum did not recognise murine CENP-B or -C (del Mazo et al. 1987). The gene discussed is CENPB; the disease is lymphoma.