Based on the history of pediatric obesity and high suspicion of genetic contribution to weight gain, genetic testing was performed, and the variant c.574G > A p.(Val192Ile) and the variant c.661 A > G p.(Asn221Asp) were detected, both in heterozygosity, in the UCP3 and PCSK1 genes, respectively. The gene discussed is UCP3; the disease is Obesity.