CCKBR and Anxiety: Since gastrin-releasing peptide in the basolateral amygdala has been implied in conditioned fear [55], and CCK-4 and its synthetic analogue tetragastrin have been shown to potently induce panic attacks via the CCK-B/CCK-2 receptor [56], it could be speculated that, in analogy, the presently identified decreased methylation at the GAST gene, potentially increasing gene expression, might be involved in anxiety disorder pathogenesis as well.