Other exemplarily selected genes or systems displaying significantly altered DNA methylation patterns in the present analysis have previously been associated with anxiety-related phenotypes or neuronal development: For instance, one of the present top hits implicates the RIMBP2 gene in anxiety disorders, which is in line with a recent genome-wide association study (GWAS) reporting a RIMBP2 SNP to be associated with anxiety-related bruxism [53]. The gene discussed is RIMBP2; the disease is anxiety disorder.