Finally, in 618 patients with mixed anxiety disorders (PD, social anxiety disorder, agoraphobia or generalized anxiety disorder) vs. 514 controls, Hettema et al. [25] discerned 280 methylome-wide significant associations in monocytes using MBD-seq, with CpGs located in the Zinc Finger Protein 823 (ZNF823) and Fizzy And Cell Division Cycle 20 Related 1 (FZR1) genes constituting the most robust hits, and 82 hits in granulocytes. This evidence concerns the gene FZR1 and anxiety disorder.