TNF and small cell lung carcinoma: Similarly, GPX4 KO mouse small cell lung cancer (SCLC) cell lines [35] showed no release of CXCL1 (Fig. S1I).Moreover, freshly isolated primary murine lung fibroblasts (PMLFs) treated with the GPX4 inhibitor RSL3 did not show a significant release of CXCL1 and CXCL2 (Fig. S1J, K), while this was the case when they were treated to undergo apoptosis (TNF/Smac mimetic) or TNF-induced necroptosis (TNF/Smac mimetic/Emricasan) (Fig. S1L, M).