CALR and neoplasm: Together, these results suggest that IT treatment with VZV-vax and HPV16 L1165-173 induces tumor cell death and increases tumor cells’ sensitivity to CTL recognition through an increase in MHC-I molecules, expression of death receptors (FAS), expression of NK receptor ligands (Rae-1-γ) and surface exposure of a marker of immunogenic cell death (Calreticulin).