Among the genes with the highest magnitude of change were CDH3 (P-Caherin), which has been found to be overexpressed in CRC31, S100P, a calcium-binding protein P also overexpressed in CRC tissue32 and DUOX2, a NADPH oxidase considered to also play a role in the development of various carcinomas33. Here, DUOX2 is linked to colorectal carcinoma.