Several genes known to be involved in tumor formation and progression were significantly upregulated in FAP adenoma, including CAPN8, encoding for Calpain 8, a member of a family of intracellular calcium-activated neutral cysteine proteinases involved in cancer initiation, progression, and metastasis28, TSPAN1, encoding for Tetraspanin 1 which has been shown to promote growth of breast cancer cells via mediating PI3K/Akt pathway29, CEMIP, which affects the WNT and EGFR signaling pathways and is involved in the progression of various tumors30. The gene discussed is CAPN8; the disease is cancer.