Furthermore, MELC imaging demonstrated that NKp44(−)ILC3s were predominantly situated in close proximity to the duodenal epithelium in FAP patients, with multiple cells in close contact with CD31(+) endothelial cells that expressed DLL4 and DLL1 (Fig. 5e and Supplementary Fig. 6a; NKp44(−)ILC3 defined in Supplementary Fig. 6b). This evidence concerns the gene PECAM1 and Familial adenomatous polyposis.