DS synergized with Btz to decrease the glycolysis and mitochondrial respiratory capacity(Fig. S4B–E).We then used NCI-H929 cells to construct MM mouse xenograft subcutaneous tumor model and found that mice in the combination group had significantly smaller tumors and lower proliferation rate than those in the monotherapy groups, and mice in the combination group showed no significant decrease in body weight (Figs. 8E–G and S4G). This evidence concerns the gene CASC3 and neoplasm.