With regard to pathology, preeclampsia is widely understood to feature inadequate remodeling of maternal arterioles and concomitant reduced blood and oxygen availability for the placenta (Zhou et al., 1997), and higher levels of HIF-1α and/or HIF-2α protein have been observed in preeclamptic placenta (Soares et al., 2017). Here, HIF1A is linked to preeclampsia.