Previous studies show that phosphorylated AKT increases pro-survival BCL-2 proteins,35–37 and BCL-2 can stimulate mitochondrial respiration in tumor cells.38,39 Therefore, we explored whether cells exposed to YA or PC upregulate BCL-2 and pro-survival pathways, and confirmed that YA, but not OA exposure, increase BCL-2 in melanoma cells (Figure S6B), and furthermore, RNA sequencing (RNA-seq) confirms YA and PC, but not OA exposure, upregulate antiapoptotic genes (Table S4). The gene discussed is BCL2; the disease is melanoma.