CPT1A and melanoma: Furthermore, the irreversible inhibition of the fatty acyl chain transfer to the intermembrane space of the mitochondria (CPT1a) with etomoxir (Figures S2P and S2Q), or CPT1a lentiviral knockdown targeting both isoforms of CPT1a in YA-melanoma significantly reduced melanoma proliferation, OXPHOS, and ATP production (Figures S2R–S2V).