DRD2 and melanoma: For this, we inhibited OXPHOS with ONC201, an imipridone small molecule inhibitor of dopamine receptor D2 and caseinolytic peptidase, which activates mitochondrial proteolysis and powerfully impairs OXPHOS.44 We found that ONC201 (3 μM) decreased proliferation, reduced OXPHOS, ATP production, and maximal respiration of YA-melanoma and OA-melanoma cells (Figures S7C–S7G).