Intracellular lipids contribute to tumor cell adaptation and metastasis19–21; and the phospholipid lysophosphatidic acid drives mitogenic signaling via the PI3K-AKT pathway in pancreatic cancer.33,34 Therefore, we investigated whether phospholipids in YA drive PI3K-AKT signaling in YA-melanoma cells. This evidence concerns the gene AKT1 and melanoma.