APOE4 carriers with high LE8 (≥70) in women (crude RR: 0.62, p < 0.001) and men (crude RR: 0.82, p = 0.003) showed a significant reduction in all-cause dementia compared with those with low LE8 (<70), though this association lost significance after age adjustment (Supplementary Fig. S4 and Table S14). This evidence concerns the gene APOE and dementia.