ATXN1 and spinocerebellar ataxia type 1: The limited dynamics at first glance contradict earlier findings by Park et al. (2020) and Rezende et al. (2024), both suggesting that several dMRI metrics are possible biomarkers of disease progression in SCA1. However, their SCA1 cohorts had a significantly lower SARA mean, and their pre-symptomatic converters already exhibited WM alterations.