LRRK2 and neuroblastoma: But equally, activating TPC2 with TPC2-A1-P also reset deviant Ca2+ signals, both in neuroblastoma cells overexpressing LRRK2 G2019S and in iPSC-derived dopaminergic neurons expressing pathogenic LRRK2 at endogenous levels (Fig. 4), as well as movement defects in vivo (Fig. 7).