Yes‐associated protein (YAP), a central effector of the Hippo signaling pathway, has been implicated in the regulation of ferroptosis.[19] YAP has been shown to modulate redox homeostasis and iron metabolism, key factors in ferroptosis, through the regulation of antioxidant[20] and iron metabolism‐related genes.[21] Additionally, YAP interacts with p53, a well‐known mediator of DDR[22] and ferroptosis.[23] Given this, we hypothesize that hyperglycemia‐induced DDR may trigger ferroptosis in DCM via a YAP‐dependent mechanism. This evidence concerns the gene YAP1 and familial dilated cardiomyopathy.