Functional assays further demonstrated that knockdown of YAP1 via shRNA (sh‐YAP1) (Figure 7G–J), in contrast to MST1 (sh‐MST1) (Figure S7E–I, Supporting Information) or LATS2 (sh‐LATS2) knockdown (Figure S7J–N, Supporting Information), significantly alleviated hyperglycemia‐induced cardiomyocyte damage and the induction of ferroptosis. The gene discussed is YAP1; the disease is Hyperglycemia.