HIC1 and neoplasm: To clarify the role of HIC1 in GC cell growth and antitumor immunity responses, subcutaneous xenograft GC models were established by inoculating MFC cells with lentivirus encoding HIC1 into the right hips of BALB/C nude mice (immunodeficient), followed by treatment with GSDMD inhibitor DMF (10mg kg−1) until the tumor volumes reached 70 mm3 (Figure 6A–C).