It has been documented that CD8+ T cells are critical for cancer immunosurveillance by secreting cytotoxic cytokines, including Granzyme B and IFN‐γ.[24] Consequently, our primary focus centered on elucidating the correlation between HIC1 and CD8+ T cells, which was corroborated by bioinformatics databases, confirming a robust positive association. This evidence concerns the gene CD8A and cancer.