Bioinformatics database demonstrated that HIC1 engaged in the PD‐L1 expression and PD‐1 checkpoint pathway in cancer, T cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Chemokine signaling pathway and TNF signaling pathway, which were closely related with immune regulation (Figure 7A). This evidence concerns the gene CD274 and cancer.