HIC1 and gastric cancer: To elucidate the essential roles of HIC1 in the development of GC, we first identified the HIC1 expression levels by immunohistochemistry (IHC) staining in the GC tissue microarray encompassing 83 normal gastric mucosa and 97 GC tissues and found that the gene expression of HIC1 was statistically lower in GC tissues compared with normal gastric mucosa (Figure 1A–C).