More recently, emerging studies have described the critical role of pyroptosis in tumor suppression, attributed to the identification of epigenetic silencing and genetic mutations in certain gasdermins (GSDMs) among cancer patients.[20] It has been proposed that GSDMB‐ and GSDME‐dependent cell pyroptosis acted as an immunostimulating agent, curbing tumor advancement through the activation of lymphocyte cells and reshaping the immune landscape.[25] Consequently, we hypothesized that HIC1 might increase CD8+ T cell infiltration into tumors by regulating pyroptosis. The gene discussed is GSDME; the disease is cancer.