Importantly, MM and c‐RGD‐decorated liposome together offer BBB crossing, tumor targeting, and long‐term circulation; while, the genetically overexpressed CSF1R and IL12 on MM surface contribute to effective modulation of M2‐to‐M1 macrophage repolarization and local promotion of T cell cytotoxicity in glioblastoma microenvironment, respectively. Here, CSF1R is linked to neoplasm.