NEDD4L and neoplasm: Additionally, SMURF1 functions as a tumor suppressor by inducing the ubiquitination and degradation of TRIB2, AXIN1, MCAM and SRSF5.[46] Thus, we speculate that SMURF1 might prevent colorectal cancer liver metastasis through mechanism other than NEDD4L‐mediated PRMT5 degradation.