NEDD4L and colorectal cancer: NEDD4L C821A overexpression failed to prevent colorectal cancer liver metastasis, and NEDD4L R776Q overexpression prevented colorectal cancer liver metastasis more potently than did NEDD4L wild‐type overexpression (Figure 1F), suggesting that the E3 ligase activity of NEDD4L is important for its ability to prevent metastasis.