WEE1 and cancer: The AKT/mTOR signaling pathway is one of the most frequently altered pathways in human cancers.[57, 58] Cancer cell proliferation is regulated mainly through AKT‐mediated activation of the protein kinase mTORC1.[59] Both the dysfunction of AKT regulators and genetic alterations in AKT cause overactivation of the AKT pathway in various human cancers.[27] Posttranslational modifications of AKT, such as methylarginine, lysine modifications, and tyrosine phosphorylation, are important for AKT hyperactivation in cancers.[59] Yin et al.