K302, K329, K333, K343, K354, K380, and K387 on PRMT5 are mainly involved in this process.[29] The E3 ligase UBR7 ubiquitinates and degrades PRMT5 through K48‐linked ubiquitination at the K227 and K240 residues of PRMT5, contributing to gemcitabine resistance in pancreatic cancer.[30] Furthermore, E6AP, which also belongs to the HECT family like NEDD4L, ubiquitinates and degrades PRMT5.[31] However, in colorectal cancer liver metastasis, the E3 ligase that regulates the ubiquitination and degradation of PRMT5 has not yet been identified. The gene discussed is PRMT5; the disease is colorectal cancer.