Comorbid TDP-43 pathology has been shown to contribute to greater cognitive decline, but our results and previous work fail to demonstrate a similar link to NPS.12,54 Despite the high prevalence of co-pathologies in AD, the lack of any additional association between LBD or TDP-43 and MBI suggests that in individuals at risk of AD dementia, NPS as operationalized by MBI criteria might be a more specific correlate of ADNC. This evidence concerns the gene TARDBP and Mental deterioration.