Notably, Mei acts as a unique natural molecular glue, increasing the binding affinity between PKMYT1 and the E3 ligase TRIM25 33‐fold, thereby promoting the K48‐linked ubiquitination and degradation of PKMYT1, leading to therapeutic effects against CML. This evidence concerns the gene PKMYT1 and chronic myelogenous leukemia, BCR-ABL1 positive.