As a key member of the Wee family, PKMYT1 plays an important role in the cell cycle progression of mitosis as well as in the occurrence, progression, metastasis, and poor prognosis of various solid tumors.[2, 4, 5] Despite the frequent overexpression of PKMYT1 and its established synthetic lethal relationship with CCNE1 amplification,[37] its role in CML remains understudied. Here, CCNE1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.