JAK2 and keloid: Upregulated expression of PCOLCE, along with collagen type I and IV and fibronectin, are observed in hypertrophic and keloid scars.[64, 65] BTF3 is also overexpressed in keloid fibroblasts, enhancing proliferation, migration, and activation of the JAK2/STAT3 pathway.[66] Thus, through both non‐coding and coding mechanisms, CircGLIS3(2) regulates multiple aspects of fibrosis across subcellular compartments.