BTF3 is an oncogenic transcription factor that promotes the growth of various cancer cells.[38] We knocked down BTF3 in human dermal fibroblasts using siRNA (Figure 6H; Figure S6F, Supporting Information), which led to reduced cell growth, altered cell cycle progression, and decreased expression of proliferation regulators, including Ki67, CDK2, CCNE1, and FoxM1—a key transcription factor involved in cell proliferation and cell fate decision[39] (Figure 6I,J; Figure S6G,H, Supporting Information). This evidence concerns the gene CDK2 and cancer.