β2GPI is important in the pathophysiology of APS, which is typically characterized by (venous and/or arterial) thrombosis and/or an adverse pregnancy outcome (e.g., unexplained pre-fetal and fetal death, pre-eclampsia (PE), and placental insufficiency with severe features) in the presence of persistent laboratory evidence of aPL [1]. The gene discussed is APOH; the disease is deep vein thrombosis.