THBD and HELLP syndrome: If β2GPI oxidation affects sFlt-1 secretion in the placenta and excessive sFlt-1 affects circulating β2GPI levels, β2GPI may be involved the pathophysiology of HELLP syndrome because together with C-reactive protein and thrombomodulin, β2GPI is the only protein with a dual function of up- and down-regulating the complement and coagulation systems in response to external stimuli [63].