Interestingly, loss-of-function variants in the GALNT3 gene (protein name: GalNAc-T3) and hence a lack of degradation-protective glycosylation of FGF23 leads to systemic hyperphosphatemia and severe testicular microcalcifications (Garringer et al., 2007; Campagnoli et al., 2006; Kato et al., 2006). The gene discussed is FGF23; the disease is hyperphosphatemia.