Does implementing a 0-hour and 1-hour (hereafter referred to as 0/1-hour) high-sensitivity cardiac troponin I (hs-cTnI) protocol reduce health care resource utilization compared with a 0/3-hour standard protocol for myocardial infarction exclusion in US emergency departments (EDs)? The gene discussed is TNNI3; the disease is myocardial infarction.