Increased GR expression occurring during adolescence, in response to stress (Isgor et al., 2004), can lead to global cerebral atrophy and reduced FA in white matter (Bourdeau et al., 2002; Chen et al., 2020; van der Meulen et al., 2022; van der Werff et al., 2014). Here, NR3C1 is linked to Cerebral atrophy.