Likewise, through a molecular pathway, an elevation in the concentration of Short-Chain Fatty Acids (SCFAs) in the plasma of obese individuals can activate carbohydrate responsive element-binding protein (CHREBP) and sterol regulatory element-binding transcription factor- 1 (SREBP1), which in turn can drive lipogenesis, increase triglyceride storage and then obesity [147, 148]. The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.