PRDM16 and obesity due to melanocortin 4 receptor deficiency: According to numerous studies, a number of medications, such as resveratrol [466], rutaecarpine [467], acadesine (AICAR), metformin [468], rosiglitazone [469], and liraglupeptide [470], can reduce obesity and diabetes by altering the expression and function of PRDM16.