METTL14 and obesity due to melanocortin 4 receptor deficiency: Mettl14f/f mice were fed a HFD for 10 weeks (inducing obesity and metabolic disorders) and transduced with AAV8‐TBG‐Cre vector to specifically delete hepatic Mettl14 (AAV8‐TBG‐GFP as control) (Figure 1E).