METTL3 and obesity due to melanocortin 4 receptor deficiency: Likewise, liver METTL3 and METTL14 are also upregulated in humans with obesity and diabetes.[16] METTL3 and METTL14 in white blood cells are elevated in patients with type 2 diabetes.[17] Consistently, total liver RNA m6A levels and the level of m6A‐marked G6pc mRNA were significantly higher in HFD fed mice relative to normal chow‐fed mice.