Likewise, liver METTL3 and METTL14 are also upregulated in humans with obesity and diabetes.[16] METTL3 and METTL14 in white blood cells are elevated in patients with type 2 diabetes.[17] Consistently, total liver RNA m6A levels and the level of m6A‐marked G6pc mRNA were significantly higher in HFD fed mice relative to normal chow‐fed mice. This evidence concerns the gene G6PC1 and obesity due to melanocortin 4 receptor deficiency.