CCDC80 and Alzheimer disease: Then, CCDC80 knockout mice (CCDC80−/−) and VSMC‐specific CCDC80 knockout mice (CCDC80fl/fl SM22α Cre+) treated with angiotensin II (Ang II) or Ang II combined with β‐aminopropionitrile monofumarate (BAPN) frequently develop AD with higher frequency and severity, accompanied by severe elastin fragmentation and collagen deposition.