In addition, it is controversial to study the specific expression of VSMC by Tagln‐Cre driver, and the research results of this strain still need to be carefully interpreted.[53] Second, although CCDC80 was shown to affect VSMC function by regulating their phenotypic transformation, the role of CCDC80 as a secreted protein in regulating endothelial cells, macrophages, and fibroblasts in AD requires further research. This evidence concerns the gene CCDC80 and Alzheimer disease.