CCDC80 (also known as URB, SSG1, and DRO1), a member of the coiled‐coil domain‐containing protein family, regulates several biological processes such as tumor inhibition, adipocyte differentiation, and energy metabolism.[34, 35, 36, 37] Emerging evidence has shown that CCDC80 plays a pivotal role in regulating cardiovascular remodeling and homeostasis.[14, 15, 16] Although CCDC80 reportedly accelerates atherosclerosis by decreasing lipoprotein lipase expression,[15] we unexpectedly found a protective effect of CCDC80 on AD development. This evidence concerns the gene CCDC80 and atherosclerosis.