Then, CCDC80 knockout mice (CCDC80−/−) and VSMC‐specific CCDC80 knockout mice (CCDC80fl/fl SM22α Cre+) treated with angiotensin II (Ang II) or Ang II combined with β‐aminopropionitrile monofumarate (BAPN) frequently develop AD with higher frequency and severity, accompanied by severe elastin fragmentation and collagen deposition. This evidence concerns the gene AGT and Alzheimer disease.