To determine the role of VSMC‐specific CCDC80 in AD, we generated conditional CCDC80 knockout mice in VSMC (CCDC80fl/fl SM22α Cre+) by crossing mice in which the exon 3 of the CCDC80 gene was flanked by two LoxP sites (CCDC80fl/fl) with the mice containing the SM22α Cre+ mutation (Figure S5A, Supporting Information). The gene discussed is CCDC80; the disease is Alzheimer disease.