AGT and hypertensive disorder: Hypertension is the most important risk factor for AD.[18] Approximately 80% of patients with AD experience hypertension.[19, 20] Patients susceptible to the occurrence of AD primarily manifest elevated maximum systolic and mean aortic blood pressure levels.[21] To evaluate the effect of hypertension on CCDC80−/− mice, we injected Ang II (1000 ng/kg/min) into male CCDC80−/− and WT control mice for 14 d.