According to a previous study, transplanting MCSs that have been primed to continuously secrete HGF improved cardiac function and vessel formation in an MI model.[55] In addition to improving HUVEC angiogenesis (Figure 3F), APCS CM enhanced the viability of the hCMECs exposed to a hypoxic environment (Figure 3G). The gene discussed is HGF; the disease is myocardial infarction.