SLC7A5 and Uterine leiomyoma: In an in vitro experiment, uterine leiomyoma cells exposed to mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) at doses of 0.16, 1.6, and 16 μM for 22 weeks found that phthalate significantly increased the levels of Trp and KYN and induced the expression of Trp transporters SLC7A5 and SLC7A8 as well as TDO2, thereby inhibiting the apoptosis of uterine leiomyoma cells [82].