Furthermore, Živančević et al. explored the role of oxidative stress, particularly involving SOD2, in neurodegeneration induced by toxic metal mixtures (Pb, methylmercury, Cd, and As), offering new insights into shared molecular mechanisms underlying amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD) [34]. This evidence concerns the gene SOD2 and early-onset autosomal dominant Alzheimer disease.