We first established B[a]P-induced bronchial epithelial malignant transformed cells (HBE-P35), detected the changes in YTHDF1 and m6A levels in lung cancer and malignant transformed cells, and then used proteomics, MeRIP, and RIP to probe the upstream and downstream regulatory proteins of YTHDF1. Here, YTHDF1 is linked to lung carcinoma.