Based on the above findings, it can be speculated that polystyrene MPs and Cd induce intestinal damage and liver inflammation in broilers by interfering with the TLR4/MyD88/NF-κB pathway and the homeostasis of intestinal flora, and the toxicity of combined exposure is lower than that of single exposure because of the adsorption of polystyrene MPs. The gene discussed is NFKB1; the disease is Hepatitis.