According to the literature, neuropeptides can stimulate keratinocytes to produce pro-inflammatory cytokines (e.g., IL-1α, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, etc.)and thus enhance cell migration and antigen expression, influence the presentation of antigens (through Langerhans cells), induce mast cell degranulation with the release of mediators (like histamine) and trigger blood mononuclears to release pro-inflammatory cytokines, which could trigger inflammatory dermatoses like AD [70,71,72]. Here, IL1A is linked to Alzheimer disease.