Importantly, since the ILF has recently been identified as a distinct hippocampal projecting pathway by means of super-high-resolution diffusion-weighted imaging in vivo [26], it seems plausible that a structurally impaired ILF deprives the HC of sensory information input, hindering memory formation and retrieval [72] with subsequent hippocampal atrophy [71,73]. Here, FOXK2 is linked to hippocampal atrophy.