Cognitive impairment and the pathogenesis of neurodegenerative states are clearly influenced by neuroinflammation, endothelial activation, endothelial cell hyperplasia, the attachment of white blood cells to the endothelial damaged walls with the reduction of the lumen vessel, high plasmatic concentrations of endothelin-1, and the breakdown of the blood–brain barrier [74,75]. The gene discussed is EDN1; the disease is Cognitive impairment.