SMC4 and Familial prostate cancer: Lymph nodes are usually the first sites of metastases for prostate tumors, followed by metastases to the lungs, liver, and bones.[18] In this study, we used a prostate cancer cell line that shows prominent metastases to the lungs (RM1‐LM, an organ‐specific metastatic cell line that we developed) to detect underlying tumor mechanisms (Figure 3A), and found that SMC4 was highly expressed in RM1‐LM cells.