Previous studies showed that the expression level of SMC4 was abnormally high in the pathogenesis and progression of lung cancer, liver cancer, breast cancer, and colon cancer.[10, 11, 12, 13] SMC4 overexpression also promoted lung adenocarcinoma progression and acted as an independent prognostic factor,[10] and SMC4‐mediated glioma cell aggressiveness ensued via the TGFβ/Smad‐signaling pathway.[14] In breast cancer cells, SMC4 regulates expression of the P53 pathway genes, and this may relate to the alterations in chromosomal stability. Here, SMC4 is linked to malignant colon neoplasm.