Compared to the SMC4 knockdown cells, the RM1‐LM‐Vector cells showed enhanced lung metastasis (Figure 5A,E), and our H&E and IHC results revealed that RM1‐LM‐Vector cells increased lung metastasis and colonization relative to SMC4 knockdown cells, suggesting that loss of SMC4 suppressed prostate cancer metastasis in addition to tumor growth (Figure 5F,G). The gene discussed is SMC4; the disease is Familial prostate cancer.