HIF1A and hepatocellular carcinoma: also demonstrated that SMC4 was transcriptionally regulated by hypoxia‐inducible factor‐1 (HIF‐1) under hypoxic conditions in hepatocellular carcinoma.[23] In this study, we found that Rheb and p‐mTOR expression levels were increasingly decreased in SMC4‐knockdown cells (Figure 8H).