Because inflammatory mediators secreted from the tumor-like synovium in RA joints drive bone destruction in this disease, effects of CURC vs. TEO on human RA synoviocyte IL-1β-stimulated secretion of the bone-destroying parathyroid hormone-related protein (PTHrP) or prostagalandin-E2 (PGE2) were also examined [35,48,49,50]. This evidence concerns the gene PTHLH and neoplasm.