In contrast, CURC vs. TEO effects on PTHrP secretion, which drives bone loss in both the arthritis and breast cancer models, varied by cell type (human synoviocyte vs. breast cancer cells) and/or stimulus (IL-1β vs. TGFβ), as both blocked IL-1ß stimulated PTHrP secretion from synoviocytes while only CURC-containing extracts blocked TGFβ-stimulated PTHrP secretion from breast cancer cells. This evidence concerns the gene IL1B and arthritic joint disease.