This includes SNPs in genes such as the fat mass and obesity-associated (FTO) (rs9939609), melanocortin 4 receptor (MC4R) (rs17782313), tumor necrosis factor-alpha (TNF) (rs1800629), and IL6 (rs1800795) [17,18,19]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.